Food safety: four simple rules
During treatment immunity is weakened, so germs carried by food are more dangerous. Food safety rests on four rules: clean, separate, cook and chill. This section sums up the neutropenic eating rules from “Handwashing: the simplest protection” and “Eggs and dairy: safe choices”.

01Short answer
02Simple explanation
Clean.
Separate.
Cook thoroughly.
Chill within 2 hours.
03Scientific explanation
WHO Five Keys: cleanliness, separation, proper cooking and temperature control are the basis of preventing foodborne infection.
ESPEN: enough energy and protein matter for preventing weight and muscle loss in people with cancer, and nutritional status should be assessed regularly.
NCI: practical eating tips exist for treatment side effects such as nausea, taste changes and mouth sores.
04What happens in the body?
Who needs it most?
Neutropenia, transplant and steroid treatment; your team will tell you your own rules.

Eating out
Avoid buffets, street food and salad bars with raw items.

Dietitian
If you are losing weight, have no appetite or need a special diet, ask to see the hospital dietitian.
Food safety
Food-safety rules for neutropenia (see “Handwashing: the simplest protection” and “Eggs and dairy: safe choices”) apply at every stage.
05Nutrition: four steps
Assess, swap the risky, cook safely, eat regularly.







06Key points at a glance
| Topic | In brief |
|---|---|
Who needs it most? | Neutropenia, transplant and steroid treatment; your team will tell you your own rules. |
Eating out | Avoid buffets, street food and salad bars with raw items. |
Dietitian | If you are losing weight, have no appetite or need a special diet, ask to see the hospital dietitian. |
Food safety | Food-safety rules for neutropenia (see “Handwashing: the simplest protection” and “Eggs and dairy: safe choices”) apply at every stage. |
07Key terms
- Cross-contamination
- Germs passing from raw to ready-to-eat food.
- Pasteurisation
- Heat treatment that kills germs.
- Dietitian
- A nutrition specialist.
- Protein
- A nutrient for repairing muscles and tissues.
- Neutropenia
- Low neutrophils.
08Key points
- Four rules.
- The 2-hour rule.
- Avoid raw and unpasteurised.
- A diet is not a treatment.
- Talk to a dietitian.
09Frequently asked questions
How long do these rules apply?
Your team will say; after transplant it may be longer.
How do I wash fruit and vegetables?
Thoroughly under running water; see “Meat and poultry: safe cooking and temperatures”.
Can a special diet cure leukemia?
No. Good nutrition helps you cope with treatment, but it does not cure.
10Questions for your doctor
Take these questions to your appointment. The ones you save are collected on the “My questions” page and stay on this device only.
How long do these rules apply?
How do I wash fruit and vegetables?
Can a special diet cure leukemia?
12Sources
- WHO. Five Keys to Safer Food
- National Cancer Institute. Eating Hints: Before, During, and After Cancer Treatment
- ESPEN. ESPEN practical guideline: Clinical Nutrition in cancer (2021)
- Leukemia & Lymphoma Society. Food and Nutrition
- World Health Organization. Healthy diet fact sheet
- U.S. FDA. Talking About Juice Safety: What You Need to Know
- IDDSI. Framework
- FDA. Refrigerator Thermometers
- National Cancer Institute (NCI). Complementary and Alternative Medicine (CAM)
- National Cancer Institute (NCI). Oral Complications of Chemotherapy and Head/Neck Radiation (PDQ®) – Patient Version
Who needs it most?
Eating out